8/22/2023 0 Comments Globus simulation 2017 year 7In 2014, Kanda et al 1 first reported the development of progressively increasing signal intensity in the globus pallidus (GP) and dentate nucleus (DN) on unenhanced T1-weighted imaging in patients who had undergone multiple contrast MRIs with the administration of gadopentetate dimeglumine or gadodiamide. Because gadolinium is an extremely toxic substance, chelating agents are designed to prevent release of gadolinium in the body before renal excretion. All GBCAs are composed of gadolinium and a chelating agent. Gadolinium-based contrast agents (GBCAs) are extensively used in evaluating both central nervous system and non-CNS pathologies with MR imaging and provide critical diagnostic and treatment-guiding information. ABBREVIATIONS: DN dentate nucleus GBCA gadolinium-based contrast agent GP globus pallidus MCP middle cerebellar peduncle TH thalamus
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